Cherokee High School is one of six public high schools of the Cherokee County School District in Cherokee County, Georgia, United States. It is located in Canton. Established in 1956, it replaced Canton High School, the county's first high school.

Notable alumni

• Keith Blackwell, former Georgia Supreme Court Justice
• Brittain Brown, football player
• Chance Cain, baseball player
• Jayson Foster, football player
• Josh Holloway, actor
• Chad Jenkins, baseball player
• Eric Mayo, baseball player
• Chris Singleton, basketball player
• Montrell Washington, football player