City Railway Colony (Urdu: سٹی ریلوے کالونی) is a neighbourhood in Saddar Town in Karachi, Pakistan, and is part of the administrative district Karachi South.

The colony is comprising the entire area south of the Karachi City Station and the I. I. Chundrigar Road between the Railway Street with the MagnifiScience Centre is in the west and the Jinnah Courts and PIDC Bridge on the east. The KPT container terminal and the Moulvi Tamizuddin Khan Road builds the southern border.

There are several ethnic groups including Muhajirs, Sindhis, Punjabis, Kashmiris, Seraikis, Pakhtuns, Balochis, Memons, Bohras Ismailis.

Main areas

• Bottle Ghali
• New Challi
• Pakistan Chowk
• Serai Quarters
• Gate No.10
• N.T.R. colony
• Gharibabad