The 3,750-acre (15.2 km) Clarence Cannon National Wildlife Refuge is located in the floodplain of the Mississippi River, adjacent to Pool No. 25 in Pike County, Missouri. The refuge's diversity of habitats supports waterfowl, wading birds, shorebirds, and songbirds. Although it is protected by a levee, the refuge provides flood storage in periods of high water.

Clarence Cannon Refuge is managed by Great River National Wildlife Refuge, which is part of the Mark Twain National Wildlife Refuge Complex.

• Clarence Cannon

• Refuge website

 This article incorporates public domain material from websites or documents of the United States Fish and Wildlife Service.

• Media related to Clarence Cannon National Wildlife Refuge at Wikimedia Commons