Clarkson is an unincorporated community in Milam County, Texas, United States. According to the Handbook of Texas, the community had a population of 10 in 2000.

A post office was established at Clarkson in 1889 and remained in operation until 1906. Its population was reported as 50 in the 1940s, a figure which declined to 10 from 1990 through 2000.

Clarkson is located on Farm to Market Road 1445, 9 mi (14 km) northeast of Cameron in northern Milam County.

In 1903, Clarkson had a one-teacher school for 43 White students and a two-teacher school for 105 black students. They joined the Cameron Independent School District in the early 1950s.

• U.S. Route 77 in Texas