The Clouère (French: la Clouère, IPA: [la kluɛʁ]) is a river that flows 76.3 km (47.4 mi) through the west-central French departments of Charente and Vienne. Its source is at Lessac, from which it flows generally northwest. It is a right tributary of the Clain, into which it flows between Château-Larcher and Aslonnes.

Th Clouère flows through these communes, listed from source to mouth:

• Charente: Lessac
• Vienne: Availles-Limouzine, Pressac, Saint-Martin-l'Ars, Usson-du-Poitou, Saint-Secondin, Brion, Saint-Maurice-la-Clouère, Gençay, Marnay, Château-Larcher, Aslonnes