The Clyde River, also known as the River Clyde, part of the River Derwent catchment, is a perennial river located in the Midlands region of Tasmania, Australia.

The Clyde River rises in the reservoirs of Lake Sorell and Lake Crescent, near Interlaken and flows generally west by south, through the settlements of Bothwell and Hamilton, joined by nine minor tributaries before reaching its mouth and emptying into the River Derwent at Lake Meadowbank. The river drains a catchment area of 1,120 square kilometres (430 sq mi) in an agricultural region of Tasmania and descends 744 metres (2,441 ft) over its 97-kilometre (60 mi) course.

• Rivers of Tasmania