The Col de la Cluse (French pronunciation: [kɔl də la klyz]) is a mountain pass located 1,169 m above sea level in the Chartreuse Mountains. It connects Le Désert d'Entremont (commune of Entremont-le-Vieux) to Corbel, Savoie, France. The main road of the pass is the D45.

In winter, It is a departure to the cross country ski slopes. In summer, it is the start of a two-hour hike to access to Roche Veyrand (1,429 m), overlooking Saint-Pierre d'Entremont in Savoie. The nearby Roc de Gleisin can also be reached. It is one of the access roads to the Col du Grapillon, to the east.