Commercial Hotel, also known as the General Pershing Hotel, was a historic hotel and theater complex located in DuBois, Pennsylvania, United States. The four story brick structure opened as a two-story hotel with 58 rooms in 1889. It was enlarged to four stories and 100 rooms with an expansion in 1901. The 700 seat Harris-DuBois Theater, later the DuBois Playhouse, opened in 1937. The building has been demolished.

It was listed on the National Register of Historic Places on November 13, 1985.

See also

• Contributing property
• Cultural landscape
• Historic preservation
• Keeper of the Register
• List of heritage registers
• Property type (National Register of Historic Places)
• United States National Register of Historic Places listings
• State Historic Preservation Office