Route 354 is a state highway in eastern Connecticut running from Colchester to Salem.

Route 354 begins as Parum Road at an intersection with Route 85 in the town center of Colchester and heads southeast. It intersects Route 2 after 0.4 with a partial interchange at Exit 21. Route 354 continues southeast, becoming Deep River Road as it heads towards the town of Salem. In Salem, the road becomes Old Colchester Road and continues southeast to end at an intersection with Route 82 at the south side of Gardner Lake.

Route 354 was commissioned from SR 654 in 1963 and has had no significant changes since. SR 654 itself first became a state road in 1955. A proposal to extend it to Route 32 in Montville was rejected in 1973.

The entire route is in New London County.

Location	mi	km	Destinations	Notes
Colchester	0.00	0.00	Route 85 – Salem, Hebron	Western terminus of Route 354
	0.40	0.64	Route 2 east – Norwich	Exit 25 on Route 2
Salem	7.37	11.86	Route 82 – Montville, East Haddam	Eastern terminus of Route 354
1.000 mi = 1.609 km; 1.000 km = 0.621 mi