New Mexico State Road 45 (NM 45) is a 22.918-mile-long (36.883 km) State Highway in the US state of New Mexico that runs parallel to the Rio Grande from the Pueblo of Isleta, through Albuquerque, and to the Southern boundary of Rio Rancho.

Throughout most of Albuquerque, NM 45 is called Coors Boulevard. Coors Boulevard serves as a major expressway in Albuquerque as it allows access to Interstate 40 (I-40), and other major highways in the city such as NM 423 (Paseo Del Norte), NM 528 (Alameda Boulevard), and NM 500 (Rio Bravo Boulevard/Sen. Dennis Chaves Boulevard). NM 45 merges with NM 528 near Rio Rancho, New Mexico at Pat D'Arco Highway. Coors Bypass NW is a segment of NM 45 which runs north from Coors Road to Pat D'Arco Highway.

Until 2012, the northernmost portion of this route traversed Old Coors Road between Coors Boulevard and Central Avenue (Historic U.S. Route 66). NM 45 has since been realigned to Coors Boulevard and Coors By-Pass and extended north of Central Avenue, replacing the portion of NM 448 between St. Joseph's Drive and Coors By-Pass, and turning over Old Coors Road to local control to be realigned with Yucca Drive.

The entire route is in Bernalillo County.

Location	mi	km	Destinations	Notes
Pueblo of Isleta	0.000	0.000	NM 314	Southern terminus
	0.250	0.402	NM 317 west to I-25 / US 85	Eastern terminus of NM 317, to I-25 exit 209
South Valley–Albuquerque line	8.850	14.243	NM 500 east (Rio Bravo Boulevard)	Western terminus of NM 500
Albuquerque	14.327	23.057	I-40 – Santa Rosa, Gallup	I-40 exit 155
	20.308	32.683	NM 423 (Paseo del Norte Blvd)	Single-point urban interchange
	21.378	34.405	NM 448 north (Coors Boulevard) to NM 528	Southern terminus of NM 448
	22.918	36.883	NM 528	Northern terminus, interchange, southbound exit and northbound entrance only
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Incomplete access

• List of state roads in New Mexico

Media related to New Mexico State Road 45 at Wikimedia Commons