Cruz del Eje Department is a department of Córdoba Province in Argentina.

The provincial subdivision has a population of about 52,172 inhabitants in an area of 6,653 km², and its capital city is Cruz del Eje, which is located around 861 km from Capital Federal.

• Alto de Los Quebrachos
• Bañado de Soto
• Cruz de Caña
• Cruz del Eje
• El Brete
• Guanaco Muerto
• La Batea
• La Higuera
• Las Cañadas
• Las Playas
• Los Chañaritos
• Media Naranja
• Paso Viejo
• San Marcos Sierras
• Serrezuela
• Tuclame
• Villa de Soto

On 22 September 1908 the region was struck by an earthquake measuring 6.5 on the Richter scale. The epicentre was around 30°30′0″S 64°30′0″W / 30.50000°S 64.50000°W / -30.50000; -64.50000 and it was felt as far as 100 km away.