Dębe Wielkie [ˈdɛmbɛ ˈvjɛlkʲɛ] is a village in Mińsk County, Masovian Voivodeship, in east-central Poland. It is the seat of the gmina (administrative district) called Gmina Dębe Wielkie. It lies approximately 9 kilometres (6 mi) west of Mińsk Mazowiecki and 31 km (19 mi) east of Warsaw.

The village is the birthplace of Polish socialist revolutionary Stefan Okrzeja.