On 13 June 2019, Howell posted a video on his channel where he came out as gay, and he talked about his experiences growing up in the 90s. Lester came out by tweet the same day and, the end of June, also made a coming out video where he went into more detail than in his tweet.

In 2011, Dan and Phil created a collaborative YouTube channel through the network My Damn Channel. Titled The Super Amazing Project, it featured the duo discussing and investigating paranormal events. Segments included "Viewers Spooky Happenings", where the audience of the show would send in "scary" items for the video bloggers to react to, and "In The News This Week", where the duo recapped recent light-hearted news items and viral videos. In October 2014, it was announced that as of that month Dan and Phil would not carry on working on The Super Amazing Project in order to concentrate on their Radio 1 show. Dan and Phil later announced that the Super Amazing Project would be hosted by new presenters, Alastair James Murder and Victoria Atkin, found by channel owners My Damn Channel.

On 12 September 2014, Dan and Phil posted the first video on their new gaming YouTube channel, DanAndPhilGAMES. On 8 March 2015 the channel hit 1 million subscribers. It was officially the fastest growing channel on YouTube. DanAndPhilGAMES reached over 3.1 million subscribers. Popular recurring and annual series on this channel include their Sims 4 (starring their joint Sim Dil Howlter) and Google Feud series, Dan vs Phil, Spooky Week, and Gamingmas. In December 2018, the channel went on an indefinite hiatus.

On 15 October 2023, Dan and Phil announced that they would both return to making videos on the channel in a parody video titled Saying Goodbye Forever, directed by PJ Liguori and guest starring Jacksepticeye. For the channel's return, they commissioned a custom lo-fi and synthwave-inspired soundtrack, released as an album titled All or Nothing under the artist name DanAndPhilBEATS in February 2024.

For Lester's birthday in January 2024, the pair hosted a two-hour charity livestream on the channel, through which they raised over $100,000 for the Palestine Children's Relief Fund.

In November 2012, the BBC announced that from January 2013 onwards, Dan and Phil would present the Sunday night entertainment and request show for national UK radio station BBC Radio 1. The duo had occasionally worked with Radio 1 before, making videos for the station's YouTube channel and presenting two Christmas broadcasts.

The show was designed to be an interactive, audio-visual broadcast involving music videos made by viewers, physical challenges performed on air by Dan and Phil, and song requests from listeners. It was streamed in a video, live on the BBC Radio 1 website, and accessible worldwide.

In August 2014, it was announced that the last Dan and Phil show would be broadcast on 24 August, with the duo moving to a different show on Monday nights, featuring other popular video bloggers. This new show was titled The Internet Takeover, and featured Lester alongside Howell live on the first Monday of every month, before coming to an end in April 2016.

In 2013, Dan and Phil appeared on Friday Download, a BAFTA award-winning CBBC TV show.

From 2014 to 2016, Dan and Phil hosted the worldwide YouTube livestream of the Brit Awards as well as making backstage videos for their channel.

In 2015, Dan and Phil had voice cameo appearances in the UK cinema release of Walt Disney Animation Studios' Big Hero 6 as Technician 1 & 2. However, this version is not in the UK home release. That same year, the duo also guest-starred in fellow YouTuber PJ Liguori's online series Oscar's Hotel for Fantastical Creatures, voicing anthropomorphic food items Brie and Rash.

In December 2016, Dan and Phil voiced two gorilla princes named Majinuni and Hafifu respectively, in the episode "The Lost Gorillas" in Disney Junior's The Lion Guard.

In 2014, Phil Lester's brother, Martyn, co-founded IRL Digital, Ltd., a company that creates and sells the merchandise of various other media personalities, starting with Dan and Phil Shop and branching out from there.

In August 2015, Dan and Phil created an app, The 7 Second Challenge, based on a YouTube challenge started by Lester in a 2014 video on his main channel. The app was discontinued in 2019. In October 2017, the duo released a party board game via Big Potato, Truth Bombs, also the brainchild of Lester. They later leased Truth Bombs to Warner Bros for a Mean Girls-themed version of the game.

On 26 March 2015, Dan and Phil announced via a trailer on Howell's channel that they had co-written a book titled The Amazing Book Is Not on Fire (TABINOF). It was released in the UK on 8 October 2015 and worldwide on 15 October 2015, published by Ebury Press and Random House Children's Books. The book topped the General Hardbacks Sunday Times Bestsellers list having sold 26,745 copies in the UK in the first week of its release. It also became a #1 New York Times Bestseller in the young adult hardcover list.

In the same trailer the pair announced their theatrical stage show The Amazing Tour Is Not on Fire (TATINOF), which travelled around the UK during October and November 2015, ending with a show at the London Palladium. During the tour, they sung original song "The Internet Is Here", which they later released as a charity single for Stand Up To Cancer, earning them a gold record disc for the sales of the song.

In 2016, they took the tour to the US and Toronto, starting with a show in Orlando, Florida on 22 April and ended on 24 June with a show at the Dolby Theatre in Hollywood, California. It was the largest tour ever achieved by YouTube creators. They later toured Australia in August 2016, starting in Perth and ending in Brisbane, and finished the tour with a European leg, performing in Stockholm, Berlin, and Dublin.

In October 2016, The Amazing Tour Is Not on Fire was released as a YouTube Red Original film by the same name along with a documentary, Dan and Phil's Story of TATINOF. They are the first British YouTube creators to release content on the YouTube Red platform.

Alongside these films, they released a photo book, Dan and Phil Go Outside, in November 2016, which includes a personal collection of candid photos and insightful stories from the tour. The book became a #1 New York Times bestseller.

In November 2017, Dan and Phil announced their second tour, Interactive Introverts, a world tour that took place in 2018. The tour ran from April, starting in Brighton, to September, ending in Mumbai, and included 80 shows in 18 countries, making it one of the biggest YouTuber tours of all time.

Dan and Phil partnered with BBC Studios' TalentWorks to release a movie of Interactive Introverts with bonus features, such as behind the scenes content and director's commentary, on DVD, Blu-ray, and available for digital download in December 2018.

In June 2024, Lester and Howell announced their third joint tour titled Terrible Influence, which would begin that September in Antwerp. From there, the tour stretches across the autumn into 2025 with dates in mainland Europe, North America, Australia and New Zealand, and the UK and Ireland. Further UK dates were added in July due to demand.

Dan and Phil met on the Internet in 2009 and in person that October. They have lived together since August 2011, first in Manchester before moving to London in July 2012. In June 2019, Howell revealed that the two have been romantically involved but refrained from discussing their current relationship, stating "I'm somebody that wants to keep the details of my personal life private. So is Phil."

A 2024 YouGov survey asked young LGBTQ+ Britons (16–25) which public figures made a "positive impression" on them growing up in terms of making them feel more comfortable and less alone in their identities. Though the list was "long and widely varied", Dan and Phil came second and fourth respectively.