Daniel Boone School is a historic school building located in the Northern Liberties neighborhood of Philadelphia, Pennsylvania. It was designed by Irwin T. Catharine and built in 1926–1927. It is a four-story, eight bay brick building with a two-story center section in the Late Gothic Revival-style. It features an off-center entrance with arched limestone surround, decorative tile mosaic panels, and a decorative brick and tile cornice. It is named for frontiersman Daniel Boone (1734-1820).

It was added to the National Register of Historic Places in 1988.