De La Salle School, Eccleston, St Helens is an 11-16 mixed comprehensive Roman Catholic high school which is linked to the worldwide La Sallian community. The school in its current form was created in 1987 after the amalgamation of several Roman Catholic high schools in the area (West Park, Notre Dame, St. Edmund Campion and Mount Carmel). Its trustees are the De La Salle Brothers, who have a house nearby.

There are 1200 pupils, and about 140 staff.

Two of the former schools were called West Park Grammar School and Notre Dame High School, which were both direct grant grammar schools.

The first statement in the Brothers' History of the House was: "September 18, 1911. The school was opened today by our Brothers. The Brothers are Brother Nilus, Brother Alphonse and Brother Francis. We commenced with 37 pupils."

Twelve years earlier in 1899, Father Hearne, the parish priest of Sacred Heart, had bought a house in St George's Road and set up a Catholic school for boys to complement the school for girls opened by the Sisters of Notre Dame. It was recognised as a Secondary School and was receiving small grants from the St Helens Education Committee. The Education Committee subsequently withdrew grants on the grounds of inadequate accommodation and insufficient teaching facilities. The agreement by which the Brothers took over Father Hearne's School in 1911 provided for his house to become the Brothers' residence with adjoining stables becoming two classrooms. In 1911 Brother Nilus opened with 37 pupils. In 1912 the number of students was 100.

The school completed a large building programme in June 2013. Nearly half of the building stock was rebuilt, while almost all of the remainder was remodelled.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (August 2022)

• Steve Prescott (1973–2013) - international rugby league player
• Paul Wellens (b. 1980) - rugby league player, St Helens RLFC
• Michael Parr (b. 1986) - actor
• Emma Rigby (b. 1989) - actress
• Stephanie Davis (b. 1993) - actress
• Jason Gilchrist (b. 1994) - footballer
• Andrew Langtree, actor
• David Tench, musician

• David P. Houghton (b. 1966) - Professor of National Security Affairs, Naval War College
• Johnny Vegas (b. 1970) - comedian

• Bernie Clifton (b. 1936) - entertainer
• Ray Connolly (b. 1940) - screenwriter
• Tom Brophy (b. 1942) - rugby player
• Chris Hesketh (1944–2017) - rugby player
• Sean Hughes (1946–1990) - history teacher, Labour MP, Knowsley South (1983–1990)
• Pete Postlethwaite (1946–2011) - actor
• Ian Lenagan (b. 1946) - businessman, Chairman English Football League
• Brendan O'Neill (b. 1948) - businessman, Executive ICI
• Pete McCarthy (1951–2004) - comedian and television presenter
• John P. Burrows FRS (b. 1954) - Professor of Physics of the Ocean and Atmosphere
• Frank Cottrell-Boyce (b. 1959) - screenwriter
• Andy Platt (b. 1963) - rugby player
• Kevin Simms (b. 1964) - rugby player
• Mick Burke (b. 1941) - mountaineer

• Liz Twist (b. 1956) - Labour MP Blaydon (2017–)
• Kathryn Mitchell (b. 1963) - academic, Vice-Chancellor University of Derby
• Ann Williams (b. 1965) - Olympic athlete