The Desjardins Canal disaster was a rail transport disaster near Hamilton, Canada West. The train wreck occurred at 6:15 p.m. on March 12, 1857 (1857-03-12) when a train on the Great Western Railway crashed through a bridge over the Desjardins Canal, causing the train and its passengers to fall 18 metres (60 ft) into the ice below. With 59 deaths, it is considered one of the worst rail disasters in Canadian history.

The train had ninety passengers. Most in the last train car survived but others on the train either drowned or succumbed to injury. Locomotive lamps and fires were built to illuminate the scene to aid in rescue efforts. Ropes and ladders were lowered to bring the dead and wounded out of the train cars. One car, partially submerged, was accessed with axes by rescuers.

• List of rail accidents in Canada
• List of rail accidents (before 1880)

• Bonikowsky, Laura Neilson (March 12, 2013). "Great Western Rail Disaster". The Canadian Encyclopedia. Historica Canada. Retrieved April 22, 2021.
• Freeman, Bill (2006). "Chapter 3: The Railroad Town (1840 – 1865)". Hamilton: A People's History. James Lorimer & Company. ISBN 978-1-55028-936-7.
• McIver, Don (2013). End of the Line: The 1857 Train Wreck at the Desjardins Canal Bridge. Toronto: Dundurn Press. ISBN 9781459702226.

43°16′47″N 79°53′27″W / 43.279611°N 79.890904°W / 43.279611; -79.890904