The Roman Catholic Diocese of Cayenne (Latin: Dioecesis Caiennensis; French: Diocèse de Cayenne) (erected 1651, as the Prefecture Apostolic of French Guiana-Cayenne) is a suffragan diocese of the Archdiocese of Fort-de-France. It was elevated on to the Vicariate Apostolic of French Guiana-Cayenne on 10 January 1933 and to the Diocese of Cayenne on 29 February 1956. The seat of the bishop is in Cayenne Cathedral.

• Giustino Fabre (1923–1924)
• Leone Delaval, C.S.Sp. (1925–1932)
• Pierre-Marie Gourtay, C.S.Sp. (1933–1944)
• Alfred Aimé Léon Marie, C.S.Sp. (1945–1973)
• François-Marie Morvan, C.S.Sp. (1973–1998)
• Louis Albert Joseph Roger Sankalé (1998–2004), appointed Coadjutor Bishop of Nice
• Emmanuel Lafont (2004–2020)
• Alain Ransay (2021–present)

• List of Roman Catholic dioceses in South America

• Eglise Catholique De Guyane, Diocese De Cayenne official site
• "Diocese of Cayenne". Catholic-Hierarchy. Retrieved 24 February 2007.

4°56′24″N 52°19′53″W / 4.94000°N 52.33139°W / 4.94000; -52.33139