The Roman Catholic Diocese of Keimoes–Upington (Latin: Dioecesis Keimoesana–Upingtonensis) is a South African diocese located around the towns of Keimoes and Upington (ZF Mgcawu District Municipality, Northern Cape) in the ecclesiastical province of Bloemfontein.

• June 20, 1885: Established as Apostolic Prefecture of Orange River from the Apostolic Prefecture of Cape of Good Hope, Central District
• May 2, 1898: Promoted as Apostolic Vicariate of Orange River
• July 9, 1940: Renamed as Apostolic Vicariate of Keimoes
• January 11, 1951: Promoted as Diocese of Keimoes
• February 8, 1985: Renamed as Diocese of Keimoes – Upington

The Cathedral is the Cathedral of the Immaculate Conception in Pella (Namakwa District Municipality). The Co-Cathedral is the Co-Cathedral of St. Augustine in Upington.

• Vicars Apostolic of Orange River (Roman rite)
  • Bishop Jean-Marie Simon, O.S.F.S. (1886 – 1898.05.03)
  • Bishop Anthony Gaughren, O.M.I. (1886.06.08 – 1901.01.15)
  • Bishop Jean-Marie Simon, O.S.F.S. (1898.05.03 – 1932.11.21)
  • Bishop Odilon Fages, O.S.F.S. (1932.11.21 – 1939.10.14)
• Vicar Apostolic of Keimoes (Roman rite)
  • Bishop Henry Joseph Thünemann, O.S.F.S. (1940.07.09 – 1951.01.11 see below)
• Bishops of Keimoes (Roman rite)
  • Bishop Henry Joseph Thünemann, O.S.F.S. (see above 1951.01.11 – 1962.09.12)
  • Bishop Francis Esser, O.S.F.S. (1962.09.12 – 1966.12.08)
  • Bishop John Baptist Minder, O.S.F.S. (1967.10.12 – 1985.02.08 see below)
• Bishops of Keimoes–Upington (Roman rite)
  • Bishop John Baptist Minder, O.S.F.S. (see above 1985.02.08 – 2000.07.05)
  • Bishop Edward Gabriel Risi, O.M.I. (since 2000.07.05)

• Francis Xavier Esser, O.S.F.S. (1955-1962)
• Odilon Fages, O.S.F.S. (1928-1932), as Coadjutor Vicar Apostolic

• Roman Catholicism in South Africa

• GCatholic.org
• Catholic Hierarchy
• Diocese of Keimoes–Upington Website

28°42′S 20°58′E / 28.700°S 20.967°E / -28.700; 20.967