The Roman Catholic Archdiocese of Sherbrooke (Latin: Archidioecesis Sherbrookensis) is a Roman Catholic archdiocese that includes part of the civil province of Quebec and includes the suffragan dioceses of Nicolet and Saint-Hyacinthe. It is currently led by Luc Cyr.

As of 2004, the archdiocese contains 107 parishes, 195 active diocesan priests, 107 religious priests, and 291,000 Catholics. It also has 1,012 women religious, 197 religious brothers, and 18 permanent deacons.

By 1830, Irish and French Canadian Catholics in the area worshipped at a small chapel dedicated to St. Columban. In 1874, the Diocese of Sherbrooke was created from the Roman Catholic Archdiocese of Quebec. Antoine Racine was appointed the first bishop. The following year, Racine founded the Séminaire Saint-Charles-Borromée, taught he theology for a number of years.

The following is a list of the bishops and archbishops of Sherbrooke and their terms of service:

• Antoine Racine (1874–1893)
• Paul LaRocque (1893–1926)
• Alphonse-Osias Gagnon (1927–1941)
• Philippe Desranleau (1941–1952)
• Georges Cabana (1952–1967)
• Jean-Marie Fortier (1968–1996)
• André Gaumond (1996–2011)
• Luc Cyr (2011–present)

• Georges Cabana (1952)
• André Gaumond (1995–1996)

• Alphonse-Osias Gagnon (1923–1927), appointed Bishop here

• Donald Lapointe, appointed Auxiliary Bishop of Saint-Jérôme, Québec in 2002
• Daniel Jodoin, appointed Bishop of Bathurst in Canada, New Brunswick in 2013
• Joseph Ferdinand Guy Boulanger, appointed Bishop of Rouyn-Noranda, Québec in 2020

• Archdiocese of Sherbrooke page at catholichierarchy.org retrieved July 14, 2006

45°24′10″N 71°53′34″W / 45.4027°N 71.8928°W / 45.4027; -71.8928