San Luis is a town and municipality in the Santiago de Cuba Province of Cuba. It is located 19 km (12 mi) north of Santiago de Cuba.

The city was founded in 1827 on the location of a ranch. Arrival of the railroad accelerated its development. San Luis achieved municipality status on 19 August 1898.

In 2022, the municipality of San Luis had a population of 77,519. With a total area of 498 km (192 sq mi), it has a population density of 160/km (410/sq mi).

The municipality is divided into the barrios of Dos Caminos, La Luz, Majaguabo, Monte Dos Leguas, Norte and Sur.

• It is a railroad junction
• Agriculture: processing and trading of sugarcane, coffee, fruit, coffee roasting
• Stock raising
• Mining: manganese deposits
• Industry: sugar mills Rafael Reyes (NNE) and Paquito Rosales (NE) are located nearby

• Antonio Maceo y Grajales - Liberation Army General (The Bronze Titan)
• Ibrahim Ferrer - Son Singer
• Félix B. Caignet - Writer - El derecho de nacer
• Barbara Moya Montoya -Derecho de Autor- Compositora - Canciones
• Augusto Rivero Más - Architect
• Pedro Meurice Estíu - Archbishop, Santiago de Cuba
• Luis Garzón Masabó - Artist
• Cándido Fabré - Songwriter and Singer
• Justo Salas Arzuaga - First Afro-Cuban Mayor of City of Santiago de Cuba 1940-1945/First Afro-Cuban Governor of Oriente, Cuba 1956)
• Europa Casadevall Sola (la mujer mas bella del mundo) hija de Pedro Casadevall y Maria Sola

• List of cities in Cuba
• Municipalities of Cuba

Media related to San Luis, Santiago de Cuba at Wikimedia Commons