Dotsero is an unincorporated community and a census-designated place (CDP) located in and governed by Eagle County, Colorado, United States. The CDP is a part of the Edwards, CO Micropolitan Statistical Area. The population of the Dotsero CDP was 1,172 at the United States Census 2020. The Gypsum post office (Zip Code 81637) serves the area.

Dotsero was an important railroad junction point for the Denver and Rio Grande Western Railroad's Denver to Salt Lake City line. Originally the line passed through Dotsero following the Eagle River towards Tennessee Pass and through the Royal Gorge of the Arkansas River en route to Pueblo, Colorado before turning north towards Denver. Through the years, efforts were made to have a more direct connection between Denver and Salt Lake that did not require detouring through Pueblo. The Denver and Salt Lake Railroad (D&SL) built a line west from Denver and entered the Colorado River canyon near Bond, Colorado, about 40 miles (64 km) Northeast of Dotsero. The D&SL was never finished as a separate route to Salt Lake City; however, it was eventually acquired by the D&RGW, who built a connection between Dotsero and Orestod (Dotsero spelled backwards) near Bond. This connection, commonly known as the Dotsero Cutoff, was completed on June 15, 1934 and finally provided Denver with a direct link to Salt Lake City, making Dotsero the junction between the old and new routes to Denver. After completion the old route over Tennessee pass remained in use as a secondary route, but has been dormant since 1997.

Ferdinand Hayden published an extensive survey of central and southwest Colorado in 1877, and used the location of the town of Dotsero as his "Dot Zero" (reference point) for his survey maps. The station name exists from the construction of the standard gauge railroad line to Glenwood Springs in the 1890s.

Dotsero is located at the confluence of the Eagle River with the Colorado River, along U.S. Highway 6 and Interstate 70, near the head of Glenwood Canyon, approximately 5 miles (8 km) west of Gypsum.

The Dotsero CDP has an area of 993 acres (4.017 km), including 125 acres (0.506 km) of water.

Dotsero is built at the base of Colorado's most recently active volcano, the Dotsero Volcano, which, according to the United States Geological Survey, erupted 4,140 years ago. The volcano is still classified as active by the USGS and is the only active volcano within Colorado.

The main industry at Dotsero for years consisted of making cinderblocks from the volcano.

The United States Census Bureau initially defined the Dotsero CDP for the United States Census 2010.

Dotsero CDP, Colorado

Year	Pop.	±%
2010	705	—
2020	1,172	+66.2%
Source: United States Census Bureau

• Edwards, CO Micropolitan Statistical Area

• Dotsero @ UncoverColorado.com
• Dotsero Volcanic Center
• Dotsero Volcano
• How Dotsero came by its name
• Eagle County website