Down with Israel or Death to Israel is a political slogan against Israel, which is also used in Iran and other countries such as Iraq and Mexico. Every year, Iranian pilgrims sing the slogan of "death to Israel" during the Hajj rituals and the ceremony of disavowal of polytheists. This slogan is especially chanted against Israel by demonstrators on Quds Day and is often accompanied by the burning of the Israeli flag. This slogan has also been used in the atmosphere of the Islamic Consultative Assembly of Iran. In the film released from Iran's missile exercise during Mahmoud Ahmadinejad's presidency, the slogan "Death to Israel" was written on ballistic missiles that were fired at replicas. This slogan in Iran does not mean a mere political slogan, but an expression of the vision of the Iranian government towards Israel's current in the region.

The slogan of the Houthis, the Shiite rebel group in Yemen, which Iran also supports, is "God is greater, death to America, death to Israel, curse to the Jews, victory to Islam". This slogan is also one of the slogans used by Hezbollah in Lebanon. Tariq Alhomayed believes that the slogan of death to Israel in the Arab world has lost its function and holding reconciliation agreements between the Arab countries of the region with Israel is proof of this claim. This slogan, as one of the symbols of hatred against Israel, has been noticed by the rulers of the Middle East region.

Nikki Haley, the former representative of the United States in the United Nations, in a tweet, considered this slogan, along with the slogan of death to America, as a reason to oppose Iran. She believes that Iran is looking for nuclear weapons and is seeking to realize these two slogans. Akram Meknes, one of the Arabic language writers, considers the slogan of death to Israel as an erosion slogan that does not convince even children these days and has lost its effectiveness. Karim Sadjadpour considers the slogan of death to America, along with death to Israel, as well as the hijab, to be the main foundations of the Islamic Republic of Iran's ideology, which remains for them in the 2020s. Benjamin Netanyahu, referring to this slogan, considers it a proof of the radical atmosphere ruling in Iran.

According to the Islam Quest website, this slogan is permissible due to the "tyranny of the Israeli government". Ali Al Bukhaiti, the former spokesman and the official media face of the Houthis, said: "We really do not want anyone's death. This slogan is only against the intervention of those governments [i.e. the United States and Israel]." Ali Khamenei also considered this slogan as the "slogan of the Iranian nation" and does not consider it specific to one of the Iranian cities. Masoud Jazayeri, the spokesman of the Iranian Armed Forces, also claimed in an interview that: "Cries of death to America, death to England, death to Israel, etc. did not arise overnight; That by saying this reason and that reason, it should be removed from the political discourse of nations wounded by imperialism and arrogance and domination regimes."

Habibah Jaghoori, a student of the University of Adelaide and the editor of that university's magazine, was expelled from the university after publishing an antisemitic article titled "Death to Israel". That article contains the following content:

The solution to achieving peace and establishing justice for Palestine is to demand the destruction of Israel.
Free Palestine and death to Israel.

— Jaghoori, as quoted by The Times of Israel<ref name=r28/>