East Pennsboro Area High School is a midsized, suburban, public high school that serves East Pennsboro Township, Pennsylvania. The School is located at 425 West Shady Lane, Enola in Cumberland County, Pennsylvania. It is part of the East Pennsboro Area School District (EPASD). In the 2022–2023 school year, the School's enrollment was reported as 761 pupils in 9th through 12th grades.

East Pennsboro Area High School is served by the Capital Area Intermediate Unit 15 which offers a variety of services, including a completely developed K-12 curriculum that is mapped and aligned with the Pennsylvania Academic Standards (available online), shared services, a group purchasing program and a wide variety of special education and special needs services. High school students may choose to attend Cumberland Perry Area Vocational Technical School for training in the construction and mechanical trades.

East Pennsboro High School provides an extensive co-curricular program.

Clubs and organizations

• Anil Dash, Blogger, Entrepreneur, Technologist
• Mickey Shuler, Football Player
• Mickey Shuler, Jr., Football Player

• East Pennsboro Area High School student newspaper
• East Pennsboro Area High School "Panther" Marching Band
• East Pennsboro Area School District