East Seram Regency (Indonesian: Kabupaten Seram Bagian Timur) is a regency of Maluku (province), in Indonesia. It is mainly located on the island of Seram, but also includes smaller islands to the southeast comprising the Gorom (or "Gorong") and Watubela archipelagoes. The regency covers a land area of 5,779.12 km, and had a population of 99,065 at the 2010 Census and 137,972 at the 2020 Census; the official estimate as at mid 2023 was 138,580 (comprising 70,051 males and 68,529 females). The principal town lies at Bula, on Seram Island.

At the time of the 2010 Census the regency was divided into six districts (kecamatan), an increase from the original four. The first four of these six districts were on the island of Seram; the Gorom and Watubela archipelagoes are groups of smaller islands situated to the southeast of Seram. Subsequently, six additional districts were created in 2012 by the division of the original six districts, and a further three districts were created in 2014, so that the regency is now divided into fifteen districts (kecamatan), of which ten are on the island of Seram and five on the islands to its southeast. These are tabulated below with their present areas and their populations at the 2010 and 2020 Censuses, together with the official estimates as at mid 2023. The table also includes the locations of the district administrative centres, the number of administrative villages (all classed as rural desa) in each district, and its post code.

Kode Wilayah	Name of District (kecamatan)	Area in km	Pop'n Census 2010	Pop'n Census 2020	Pop'n Estimate mid 2023	Admin centre	No. of Villages	Post Code
81.05.01	Bula	643.36	24,037	26,023	26,695	Bula	10	97521
81.05.12	Bula Barat (West Bula)	880.29		8,281	8,540	Waiketam Baru	13	97522
81.05.15	Teluk Waru (Waru Bay)	669.67		5,279	5,790	Waru	11	97524
81.05.03	Werinama	993.84	9,752	6,165	5,741	Werinama	10	97525
81.05.07	Siwalalat	847.19		6,585	6,404	Atiahu	12	97523
81.05.06	Tutuk Tolu	330.09	4,722	7,166	7,033	Air Kasar	11	97594
81.05.02	Seram Timur (East Seram)	73.35	24,018	12,181	12,255	Geser	16	97592
81.05.08	Kilmury	837.62		6,518	6,440	Kilmury	14	97591
81.05.13	Kian Darat	129.23		6,297	6,450	Watu-Watu	10	97590
81.05.14	Siritaun Wida Timur (Lian Vitu)	172.37		6,689	7,137	Keta Rumadan	10	97598
Sub-totals	on Seram Island	5,577.01	62,529	91,184	92,485		117
81.05.04	Pulau Gorom (Gorom Island)	91.30	25,249	22,156	21,787	Kataloka	24	97593
81.05.11	Gorom Timur (East Gorom)	29.29		9,420	9,426	Miran	23	97596
81.05.09	Pulau Panjang (Panjang Island)	20.59	1,913	2,691	2,648	Pulau Panjang	6	97599
81.05.05	Kesui Watubela	37.58	9,251	9,321	9,039	Tamher Timur	18	97595
81.05.10	Teor (Teor Island)	23.41	2,556	3,200	3,195	Wermaf Kampung Tengah	10	97597
Sub-totals	Gorom and Watubela archipelagoes	202.17	38,969	46,788	46,095		81

Notes: (a) The 2010 Census populations of Bula Barat and Teluk Waru Districts are included with the figures for Bula District, from which they were cut out.
(b) The 2010 Census population of Siwalalat District is included with the figure for Werinama District, from which it was cut out.
(c) The 2010 Census populations of Kilmury, Kian Dalat and Lian Vitu (or Siritaun Wida Timur) Districts are included with the figures for Seram Timur District, from which they were cut out.
(d) The 2010 Census population of Gorom Timur District is included with the figure for Pulau Gorom district, from which it and Pulau Panjang District were cut out.
(e) The 2010 Census population of Kesui Watubela (or Wakate) District excludes the figure for Teor District, which was cut out of it.