Edwin and Nora Payne Bedford House, also known as the Thomas Payne House and Benjamin Smith House, is a historic home located at Fayette, Howard County, Missouri, United States. It was built about 1860, and is a two-story, three-bay, brick I-house with a two-story rear ell. It features a wide front porch and two level porch along the side of the rear ell. The interior of the house is distinguished by a large amount of ornamental woodwork.

It was listed on the National Register of Historic Places in 1998. It is located in the South Main Street Historic District.