Est-Mono is a prefecture located in the Plateaux Region of Togo. The prefecture covers 2,599 km, with a population in 2022 of 164,460. The prefecture seat is located in Elavagnon.

Cantons of Est-Mono include Elavagnon, Nyamassila, Kamina, Morétan-Igbérioko, Kpéssi, Gbadjahè, and Badin-Copé.7°26′51″N 0°50′50″E / 7.44750°N 0.84722°E / 7.44750; 0.84722