Eticuera Creek is one of four primary tributaries that drain into Lake Berryessa in northern Napa County, California. The other three are Pope Creek, Capell Creek, and Putah Creek.

Eticuera Creek drains a watershed that is approximately 53 square miles (140 km). The creek generally drains in a north to south direction.

The upper reaches of the watershed also once supported the now defunct mining town of Knoxville.