Fairntosh Plantation is a historic plantation house and complex located near Durham, Durham County, North Carolina. It consists of two separate Georgian / Federal style houses joined in a "T"-shape. The rear section is older, and is a two-story, side hall plan structure with a center-hall plan. The larger section is a two-story, five bay by three bay structure. Also on the property are the contributing outbuildings including a two-story kitchen, slave quarters, smokehouse, dairy, office schoolhouse and other dependencies.

It was listed on the National Register of Historic Places in 1973.