File:IGPS Fitness Landscapes.png
Experimentally derived fitness landscapes mapped from point mutations represent single steps from WT sequence.
Despite significant divergence of WT in sequence space, the fitness landscapes of IGPS orthologues remain correlated (dashed
lines). Rather than traditional two-dimensional heatmaps, fitness values are displayed on a three-dimensional pinwheel,
highlighting the wide range of possible fitness effects of a single sequence step. The profiles of the pinwheels are similar,
indicating the correlation of fitness landscapes, even if WT sequences (centers of the wheels) are only 40% identical and
widely separated. Principal component analysis demonstrates a correlation between experimental fitness landscapes and
amino-acid preferences in evolved sequences.
Date
5/2/2020
Source
Author supplied
Author
Deepesh Nagarajan
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