The Way of St James has existed for over a thousand years. It was one of the most important Christian pilgrimages during medieval times. It was considered one of three pilgrimages on which a plenary indulgence could be earned;[citation needed] the others are the Via Francigena to Rome and the pilgrimage to Jerusalem.

Legend holds that St. James's remains were carried by boat from Jerusalem to northern Spain where they were buried on the site of what is now the city of Santiago de Compostela. There are some, however, who claim that the bodily remains at Santiago belong to Priscillian, the fourth-century Galician leader of an ascetic Christian sect, Priscillianism, who was one of the first Christian heretics to be executed.

There is not a single route; the Way can take one of any number of pilgrimage routes to Santiago de Compostela. However a few of the routes are considered main ones. Santiago is such an important pilgrimage destination because it is considered the burial site of the apostle, James the Great. During the Middle Ages, the route was highly travelled. However, the Black Plague, the Protestant Reformation and political unrest in 16th- century Europe resulted in its decline. By the 1980s, only a few pilgrims arrived in Santiago annually. However, since then, the route has attracted a growing number of modern-day pilgrims from around the globe. The route was declared the first European Cultural Route by the Council of Europe in October 1987; it was also named one of UNESCO's World Heritage Sites in 1993.