First Baptist Church was a historic Southern Baptist church located at 401 S. Scales Street in Reidsville, Rockingham County, North Carolina. It was built in 1918, and was a Late Gothic Revival style brick church. It has a three bay wide front facade with crenellated towers of unequal height and a three-part tracery stained glass window. It was home to an African-American Baptist congregation until the mid-1970s.

It was added to the National Register of Historic Places in 1986. It has since been demolished.