First Church of Christ, Scientist, also known as First Christian Science Church Edifice, is a church building located in Oconto, Wisconsin. Built in 1886 of stone, weatherboard and brick in the Gothic Revival style, it was the first purpose-built Christian Science church edifice in the world. It was added to the National Register of Historic Places in 1974.

First Church of Christ, Scientist, Oconto, was organized on June 10, 1886 as "the Christian Science Association of Oconto," with the building being finished in October of that year for less than $1,000; but for various reasons it was not dedicated until February 1887. Other Christian Science groups were meeting at the time around the United States, and the membership of the Oconto church did not realize they had built the first Christian Science church edifice in the world until later. Laura Sargent and her sister Victoria, who were very involved in the founding of the church, would go on to play important roles in the movement.

The building is still used for Christian Science religious services, although First Church of Christ, Scientist, Oconto, is now Christian Science Society, Oconto.

The auditorium seats 100 people.

• List of Former Christian Science Churches, Societies and Buildings

• Wisconsin historical marker Archived 2011-06-11 at the Wayback Machine