First National Bank of Seaford is a historic bank building located at Seaford, Sussex County, Delaware. It was built in 1868, and is a two-story, five-bay, rectangular brick structure in the Italianate style. It has a hipped roof with dormers and a two-story, frame addition. It is the oldest standing bank building in Seaford and has been converted to apartments.

It was added to the National Register of Historic Places in 1987.