State Road 222 (SR 222) is a 14.174-mile-long state road that serves northern Gainesville. The western terminus is at a diamond interchange with I-75 at exit 390, and the eastern terminus is at a fork at SR 26 just east of Gainesville.

It is 4 lanes wide, but narrows to 2 lanes east of Airport Access Road, where it runs along the northwestern edges of the Newnans Lake State Forest followed by the Newnans Lake Conservation Area. At its western terminus, NW 39th Avenue continues west as two lane County Road 222 towards CR 241, a long county road.

The entire route is in Alachua County.

Location	mi	km	Destinations	Notes
​	0.000	0.000	west end of state maintenance, route continues as CR 222 (Northwest 39th Avenue) to CR 241
​	0.21	0.34	I-75 (SR 93) – Lake City, Tampa, truck route to SR 24 west / SR 26 west	I-75 exit 390
Gainesville	3.667	5.901	CR 2053 (Northwest 43rd Street)
	4.664	7.506	SR 121 (Northwest 34th Street) – LaCrosse, Williston
	6.667	10.729	US 441 (Northwest 13th Street / Dr. Martin Luther King Jr. Highway / SR 25) – truck route to SR 121 north
	7.157	11.518	SR 20 (Northwest 6th Street)
	7.849	12.632	CR 329 (North Main Street)
	9.716	15.636	SR 24 (Waldo Road) – Waldo, Gainesville, Hospitals, University of Florida, truck route to SR 26 east / SR 121 south / US 441 south
	14.174	22.811	SR 26 (Northeast 55th Boulevard) – Orange Heights, Gainesville
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• Media related to Florida State Road 222 at Wikimedia Commons