The Gare de Mulhouse-Ville, also known as Gare Centrale, is the main railway station in the city of Mulhouse, Haut-Rhin, France. It is the eastern terminus of the Paris-Est–Mulhouse-Ville railway.

The station is a major thoroughfare on the SNCF network as it is the second busiest in the Alsace region after Strasbourg-Ville.

The current station was built in the years 1928–1932 and rebuilt until 1955, after sustaining heavy damage in 1944, during World War II; it was restored again in 2006, in anticipation of the TGV. Mulhouse's first railway station had been opened in 1839

Mulhouse-Ville station is connected to the LGV Rhin-Rhône high speed line, offering TGV services towards Besançon, Dijon, Paris and southern France. Regional and local services are offered by TER Grand Est. Destinations include:

• Basel
• Belfort
• Colmar
• Frankfurt
• Kruth
• Luxembourg
• Lyon
• Marseille
• Paris Lyon
• Strasbourg
• Zurich

A tram stop on the forecourt of the station serves as the terminus of lines 2 and 3 of the Mulhouse tramway, as well as the tram-train service to Thann. The outer section of this tram-train line shares its tracks with the SNCF service from inside the station to Kruth.

• Media related to Gare de Mulhouse-Ville at Wikimedia Commons
• Mulhouse-Ville station at "Gares & Connexions", the official website of SNCF (in French)