The General López Department (in Spanish, Departamento General López) is an administrative subdivision (departamento) of the province of Santa Fe, Argentina. It is located in the south of the province. Its head town is Melincué (population 2,200), and its largest city is Venado Tuerto (population 70,000).

It is bordered by the Caseros Department in the north, and by the Constitución Department in the north-east; the rest of its borders coincide with interprovincial limits (with Córdoba in the west and with Buenos Aires in the south and east).

The towns and cities in this department are (in alphabetical order): Aarón Castellanos, Amenábar, Cafferata, Cañada del Ucle, Carmen, Carreras, Chapuy, Chovet, Christophersen, Diego de Alvear, Elortondo, Firmat, Hughes, La Chispa, Labordeboy, Lazzarino, Maggiolo, María Teresa, Melincué, Miguel Torres, Murphy, Rufino, San Eduardo, San Francisco de Santa Fe, San Gregorio, Sancti Spiritu, Santa Isabel, Teodelina, Venado Tuerto, Villa Cañás, Wheelwright.

• Government of the Province of Santa Fe
• Inforama - Municipalities of the General López Department.
• "General López Department" (in Spanish). Municipal Affairs Federal Institute (IFAM), Municipal Affairs Secretariat, Ministry of Interior, Argentina.

• Media related to General López Department, Santa Fe at Wikimedia Commons