State Route 281 (SR 281) is a south–north state highway located in the northeastern part of the U.S. state of Georgia. Its route is in Madison and Franklin Counties, with a brief section straddling the Madison-Hart County line.

SR 281 begins at an intersection with US 29/SR 8 (General Daniels Avenue North) northeast of Danielsville. It heads northeast to an intersection with SR 191 (Dalton Drive). The highway crosses the Broad River, and curves into a more north-northeast routing. It passes through rural parts of Madison County and runs along the Madison-Hart County line before entering Franklin County. Almost immediately after crossing the county line, SR 281 meets its northern terminus, an intersection with SR 17 Business (Church Street) in Royston.

This section is empty. You can help by adding to it. (February 2013)

County	Location	mi	km	Destinations	Notes
Madison	​	0.0	0.0	US 29 / SR 8 (General Daniels Avenue North)	Southern terminus
	​	2.3	3.7	SR 191 (Dalton Drive) – Comer, Royston
	Broad River	4.1	6.6	Crossing over the Broad River
Franklin	Royston	11.9	19.2	SR 17 Bus. (Church Street) – Elberton	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

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