Germantown High School is a public high school in Germantown, Tennessee, and is part of the Memphis-Shelby County Schools district. Three acres were purchased in 1910, and in 1911 students moved into the new building.

By 1910, the Shelby County Board of Education had purchased three acres for a new school building serving grades one through twelve, and also in 1911, students moved into the new building with five classrooms and a study hall. Wagonettes pulled by horses or mules were also the common mode transportation at the time, but by 1918, motorized wagonettes were used.

Additional rooms and buildings were added to both sides of a WPA facade in 1918, 1919, 1927, and 1935, for the Germantown Public School.

Germantown High School offers a variety of sports: baseball, basketball, bowling, cross country, football, golf, cheerleading, soccer, softball, swimming, tennis, track and field, volleyball, wrestling, dance, and trap shooting.

• The football team won state championships in 1983 and 2003.
• The girls' soccer team won the state championship in 1994, 1999, and 2001.
• The Germantown boys' baseball team won the state championship in 1981, 1995, and 2001.
• The boys' golf team won the state championship in 1997
• The girls' volleyball team won the state championship in 1983, 1985, 1988, 1989, 1990, 2003 and 2005.
• The boys' tennis team won the state championship in 1980 and 1981.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (June 2019)

• Mickey Callaway, professional baseball coach and former Major League Baseball player
• Ian Clark, basketball player for the Xinjiang Flying Tigers
• Antonius Cleveland (born 1994), basketball player in the Israeli Basketball Premier League
• Debbie Elliott, National Public Radio broadcaster
• Austin Hollins (born 1991), basketball player for Maccabi Tel Aviv of the Israeli Basketball Premier League
• Ben Johnson, Major League Baseball player
• Paul Maholm, Major League Baseball pitcher
• Susan Marshall, vocalist, pianist, songwriter and recording artist
• Jeremy Padawer, kids toys and entertainment executive, creator of Monsuno television series on Nickelodeon
• Cindy Parlow, US women's national soccer team and U.S. Soccer executive
• Chris Parnell, Saturday Night Live actor
• Missi Pyle, actress in Galaxy Quest, Dodgeball, and Broadway show Boeing Boeing Broadway
• Eric Still, Houston Oilers offensive guard
• Tony Williams, Jacksonville Jaguars defensive tackle