The Gimone (French pronunciation: [ʒimɔn]; Gascon: Gimona) is a 136-kilometre (85 mi) river in south-western France, left tributary of the Garonne. Its source is in the foothills of the Pyrenees, near Lannemezan. It flows north through the following départements and towns:

• Hautes-Pyrénées
• Gers: Saramon, Gimont
• Tarn-et-Garonne: Beaumont-de-Lomagne

The Gimone flows into the Garonne near Castelsarrasin.