Gmina Żyrzyn is a rural gmina (administrative district) in Puławy County, Lublin Voivodeship, in eastern Poland. Its seat is the village of Żyrzyn, which lies approximately 14 kilometres (9 mi) north-east of Puławy and 44 km (27 mi) north-west of the regional capital Lublin.

The gmina covers an area of 128.73 square kilometres (49.7 sq mi), and as of 2006 its total population is 6,588 (6,538 in 2015).

Gmina Żyrzyn contains the villages and settlements of Bałtów, Borysów, Cezaryn, Jaworów, Kośmin, Kotliny, Las-Grzęba, Las-Jawor, Osiny, Parafianka, Sachalin, Skrudki, Strzyżowice, Wilczanka, Wola Osińska, Zagrody, Żerdź and Żyrzyn.

Gmina Żyrzyn is bordered by the town of Puławy and by the gminas of Abramów, Baranów, Końskowola, Kurów, Puławy, Ryki and Ułęż.

• Polish official population figures 2006