The Gotthard Pass lies on the main watershed of the Gotthard massif, a massif lying at the heart of the Swiss Alps, between the cantons of Valais, Ticino, Grisons and Uri. The pass itself is the lowest point between the summits of Pizzo Lucendro (west) and Pizzo Centrale (east). It connects the cantons of Uri (north) and Ticino (south), its summit (2,106 metres (6,909 ft), indicated by a road sign) being located in the latter canton, about 2 km south of the border with Uri. The valleys connected by the pass are that of the river Reuss, named the Urseren, and that of the river Ticino, named Valle Leventina. The Gotthard axis is the most important route between Central Switzerland as well as most of the northern part of the country and the southern region of Ticino. It is the most direct link between Zürich and Lugano and also between some regions of northern Europe and Italy (Rotterdam-Basel-Genoa axis).

The nearest towns are Hospental (7 km north) near Andermatt and Airolo (4 km south), respectively in the valleys of Urseren and Leventina. The region of Andermatt lies at the foot of the Furka and Oberalp Passes connecting the Rhone and Rhine Valleys thus making the Gotthard area a strategic place for transports and military (the Swiss Réduit for instance).

Just southeast of the culminating point of the Gotthard Pass, at an elevation of about 2,090 metres above sea level, are several lakes. The largest is named Lago della Piazza and has a surface of 3.94 hectares. South of Lago della Piazza are the Hospice (Italian: Ospizio) and National Museum, as well as a hotel and restaurants. Another official road sign displaying an elevation of 2,091 metres (6,860 ft) lies there.

A few kilometres away and slightly above the Gotthard Pass are found two large dams and artificial lakes: Lago di Lucendro at the foot of Pizzo Lucendro and Lago della Sella at the foot of Pizzo Centrale. They are respectively part of the Reuss and Ticino basin, although both are located within the canton of Ticino.

Though the pass was locally known in antiquity, it was not generally used until the early 13th century because travel involved fording the turbulent Reuss, swollen with snowmelt during the early summer, in the narrow steep-sided Schöllenen Gorge, below Andermatt.

The first wooden bridge across Schöllenen Gorge was built around 1220, and in the following years the pass rapidly gained in importance.

The bridge permitted traffic to follow the Reuss to its headwaters and over the saddle at the top—a continental divide between the Rhine, which flows into the North Sea, and the river Ticino towards Milan, which after leaving Switzerland flows into the Po and ultimately into the Adriatic Sea.

The Gotthard Pass was formerly known as Monte Tremolo (its southern slope is still known as Val Tremola).

A chapel dedicated to Saint Gotthard of Hildesheim (died in 1038, canonized 1131), who was considered the patron saint of mountain passes, was built on the southern slope of the pass and consecrated by the archbishop of Milan, Enrico da Settala, in 1230. The pass soon became known after the saint, by as early as 1236.

The opening of the Schöllenen Gorge for traffic was an important factor in the original Swiss Confederacy. The three regions of Uri, Schwyz and Unterwalden (the Waldstätten or "forest communities") gained imperial immediacy under the Hohenstaufen emperors still in the first half of the 13th century. An important aspect of the early confederacy, expressed in the Pfaffenbrief of 1370, was the guarantee of peace along the road from Zürich to the Gotthard Pass.

The Swiss also had an interest in extending their influence south of the Alps to secure the trade route across the pass to Milan. Beginning in 1331, they initially exerted their influence through peaceful trade agreements, but in the 15th century, their involvement turned military. 1403 the upper Leventina, as the valley south of the pass is called, became a protectorate of Uri. Throughout the 15th century, a changeful struggle between the Swiss and the Duchy of Milan ensued, resulting ultimately in the Swiss conquest of the territory of the Ticino.

The "Devil's Bridge" (Teufelsbrücke) legend associated with the crossing of the Schöllenen Gorge is not medieval; it may date to the 16th century (attestation of the name Teiffels Brucken in 1587) but more likely formed in the 17th century, and is first recorded in the early 18th century, by Johann Jakob Scheuchzer.

A new road, including a tunnel with a length of c. 60 m, was built in 1707/8. The tunnel, known as Urnerloch, was the first road tunnel to be built in the Alps. It was constructed by Pietro Morettini (1660–1737).

The path across Schöllenen Gorge, and thus across the pass, still carried only foot traffic and pack animals until 1775, when the first carriage made the journey on an improved road.

The Battle of Gotthard Pass took place on 24 September 1799.

The new Gotthard road was built in 1830, wide enough to allow (single-lane) motorized traffic. It is said that the first car traversed the pass in 1895. The first reported surmounting of the pass in 1901 still took more than a day.

With the Gotthard Road Tunnel (opened in 1980) the pass itself was again reduced to limited importance for traffic.

In addition to the National Road 2, crossing the pass and connecting Göschenen with Airolo, several tunnels provide access through the massif. The first one, the 15 kilometres (9.3 mi) Gotthard Rail Tunnel, opened in 1882 for railway traffic at a cost of around 200 workers' lives (there is uncertainty as to the exact toll). The second one, the 17 kilometres (11 mi) Gotthard Road Tunnel (a motorway tunnel), opened in 1980. It was closed for two months in 2001 following a fatal fire. Both railway and motorway tunnels have portals in Göschenen and Airolo, at around 1,150 metres above sea level, and are close to each other. Either rail and road traffics through these tunnels are sometimes shut down during harsh weather conditions, particularly in winter.

The last tunnel, the 57 kilometres (35 mi) Gotthard Base Tunnel (a double-tube railway tunnel), opened in 2016. At around 500 metres above sea level, it provides for the first time a flat route through the massif and the Alps from the northern plains at Erstfeld to the southern plains at Bodio. It is the longest and deepest railway tunnel in the world. This tunnel, combined with two shorter tunnels planned near Zürich and Lugano as part of the NRLA project, reduced the 3 hour 40 min rail journey from Zürich to Milan by one hour, while increasing the size and number of trains that can operate along the route because the line is nearly level, compared with the spirals of the older tunnel.

A number of international artists have been inspired by the dramatic scenery of the Gotthard Pass, the Schöllenen Gorge and the Teufelsbrücke.

• Gotthard Pass is prominent in the historical manga series Wolfsmund by Mitsuhisa Kuji.

• List of highest paved roads in Europe
• List of mountain passes
• List of the highest Swiss passes
• Tremola San Gottardo

• Clausewitz, Carl von (2020). Napoleon Absent, Coalition Ascendant: The 1799 Campaign in Italy and Switzerland, Volume 1. Trans and ed. Nicholas Murray and Christopher Pringle. Lawrence, Kansas: University Press of Kansas. ISBN 978-0-7006-3025-7.
• Clausewitz, Carl von (2021). The Coalition Crumbles, Napoleon Returns: The 1799 Campaign in Italy and Switzerland, Volume 2. Trans and ed. Nicholas Murray and Christopher Pringle. Lawrence, Kansas: University Press of Kansas. ISBN 978-0-7006-3034-9.
• Nicola Pfund, Sui passi in bicicletta - Swiss Alpine passes by bicycle, Fontana Edizioni, 2012, p. 78-87. ISBN 978-88-8191-281-0.

Wikimedia Commons has media related to Gotthard pass.

• Cycling Elevation profiles for both sides on the old road
• Free Pictures St. Gotthard Pass
• The Gotthard, Switzerland
• Sankt Gotthard Pass Archived 2015-04-02 at the Wayback Machine (in English)
• Coolidge, William Augustus Brevoort (1911). "St Gotthard Pass" . Encyclopædia Britannica. Vol. 24 (11th ed.). pp. 6–7.