The Grand Glaize Bridge is the name of two girder bridges that carry U.S. Route 54 over the Grand Glaize Arm of the Lake of the Ozarks in the city of Osage Beach, Missouri.

The bridge crosses Grand Glaize Creek that is a tributary to the Osage River in Camden County, Missouri.

The original two-lane Grand Glaize Bridge was built in 1931 during the construction of Bagnell Dam and the Lake of the Ozarks. It was a Warren truss or deck truss structure with the trusses built under the deck. Other bridges built across the lake at the time including the Hurricane Deck Bridge over the Osage Arm and the Niangua Bridge over the Niangua Arm were also deck truss structures. The only non-deck-truss bridge on the lake was the Niangua Arm US 54 Bridge. The original bridge had very narrow lanes and no shoulder.

The new parallel girder bridge carrying westbound traffic was completed in 1984. The original bridge was torn down and the new eastbound girder bridge was built in 1995 in the place of the original.

In 2023, both the eastbound bridge and westbound underwent rehabilitation by placing epoxy-wearing on the surface. Only one side was done at a time.

There has been proposals to add a pedestrian bridge adjacent to the existing bridge due to no current dedicated pedestrian walkway present.

• List of bridges documented by the Historic American Engineering Record in Missouri

• Historic American Engineering Record (HAER) No. MO-79, "Grand Glaize Bridge, Spanning Lake of Ozarks at U.S. Route 54, Osage Beach, Camden County, MO", 14 photos, 33 data pages, 1 photo caption page
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