Great Bend station was an Atchison, Topeka and Santa Fe Railway station in Great Bend, Kansas. The station was along Santa Fe's main line between Chicago and Los Angeles. It was on the "northern branch" of the main line as it split in Hutchinson, Kansas. It was also served by a line the ran to Garden City, Kansas, travelling through Ness City and Scott City. Both of these lines are now operated by the Kansas and Oklahoma Railroad. The depot was built in a Mission Revival, common for Santa Fe and Southern Pacific stations in the late 19th and early 20th centuries.

By 1953, passenger service to Great Bend consisted of the daily Chicago–Los Angeles California Limited, a daily Newton–Dodge City local round trip, and a six-day-a-week mixed train between Great Bend and Scott City. The California Limited was rerouted over the southern mainline on January 10, 1954. The northern section of the Grand Canyon was rerouted through Great Bend to replace it. The Newton–Dodge City local was discontinued on June 6, 1954; the Grand Canyon began making local stops over that segment. The Grand Canyon was rerouted away from Great Bend on September 25, 1955. The Santa Fe began operating a Dodge City–Great Bend–Newton round trip, trains 311/312, which connected with the Chicagoan and Kansas Cityan at Newton. The Great Bend–Scott City mixed train, by then down to three weekly round trips, stopped carrying passengers on April 19, 1961. Trains 311/312 were discontinued on June 13, 1965. The station building remains extant.

• Great Bend, KS depot