Greene Square is one of the 22 squares of Savannah, Georgia, United States. It is the easternmost square in the second row of the city's five rows of squares. The square is located on Houston Street and East President Street, and is south of Washington Square, east of Columbia Square and north of Crawford Square. The oldest buildings on the square are at 510 East York Street, 509 East President Street (both former properties of George Jones) and 503 East President Street (Thomas Williams House), each in the southwestern trust/civic block, which are believed to have been built at the same time as the square itself (1799).

The square is named for Revolutionary War hero General Nathanael Greene, an aide to George Washington. A native of Rhode Island, Greene commanded Southern forces during the Revolution, and after the war settled at Mulberry Grove, an estate fourteen miles (23 km) above Savannah. Greene, along with his son, is actually buried in Savannah's Johnson Square.

134 Houston Street, in the square's southeastern tything block, dates to the late 1800s. Between 1899 and the mid-1900s it was the home of the Kate Baldwin Free Kindergarten.

Greene Square was once the center of Savannah's African-American community. In the northwestern trust lot is the Second African Baptist Church, the site where Union Army general William Tecumseh Sherman announced Special Field Orders 15, better known as "40 acres and a mule".

546–548 East President Street (known as the Mary Cullum Property, now occupied by the Green Palm Inn) are two seamen's cottages, built circa 1897.

The John Dorsett House, in the northwestern tything, is the smallest free-standing house in the city, hence its nickname Tiny House. It was moved here from 422 Hull Street.

In 1967, Savannah landscape architect Clermont Huger Lee and banker Mills B. Lane planned and initiated a project to replace the cistern that caved-in, design and install shoring, close the fire lane, and install new walks, benches, lighting and planting.

Namesake	Image	Note
Nathanael Greene		The square is named for Revolutionary War hero Nathanael Greene (1742–1786).

Each building below is in one of the eight blocks around the square composed of four residential "tything" blocks and four civic ("trust") blocks, now known as the Oglethorpe Plan. They are listed with construction years where known.

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  John Dorsett House, 536 East State Street
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  538 East State Street
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  542 East State Street
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  Deitrich Oetjen House, 503 East York Street
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  Frederick Heineman Property (1), 509 East York Street
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  Teresa Neve House, 511 East York Street
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  Catherine Devaux House, 513 East York Street
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  Susannah Clarke Cottage, 517 East York Street
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  Edward White Cottage, 519 East York Street
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  Margaret McDonald House, 521 East York Street
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  Frederick Heineman Property (2), 140 Price Street
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  James King House, 113 Houston Street
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  Henry Cunningham House, 117–119 Houston Street
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  124 Houston Street, a relatively late addition to the square, as it looked during World War II
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  Jeremiah Murphy House, 129 Houston Street
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  131 Houston Street
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  Second African Baptist Church, 123 Houston Street
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  William Herman Duplex, 506–508 East York Street
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  Thomas Williams House, 503 East President Street
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  Anthony Mira House, 505 East President Street
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  Mary Cullum Property (the Green Palm Inn, as of 2022), 546–548 East President Street
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  111 East Broad Street
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  Kate Baldwin Free Kindergarten (former), 134–142 Houston Street
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  Anderson Row, 502–512 East State Street
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  Ann Rossiter House, 520 East State Street
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  Joseph Burke House, 550 East State Street