Greenup County is a county located along the Ohio River in the northeastern part of the U.S. state of Kentucky. As of the 2020 census, the population was 35,962. The county was founded in 1803 and named in honor of Christopher Greenup. Its county seat is Greenup. Greenup County is part of the Huntington-Ashland, WV-KY-OH Metropolitan Statistical Area.

Located with its northern border formed by the Ohio River, Greenup County was organized by an act of the General Assembly of Kentucky on December 12, 1803, from Mason County, which included the majority of eastern Kentucky at the time.

Three courthouses have served Greenup County. The first courthouse, built of logs, was replaced by a brick structure in 1811.

According to the United States Census Bureau, the county has a total area of 354 square miles (920 km), of which 344 square miles (890 km) is land and 10 square miles (26 km) (2.8%) is water.

Like most eastern Kentucky counties, Greenup County is predominantly made up of rolling hills and valleys. The land in the Ohio River valley is generally flat and mostly populated by industry, commerce and residential development. Beyond this the land gives way to a series of hills and valleys that are representative of the foothills of the Appalachian Mountains. It is relatively sparsely inhabited by farmers. Among these hills, popular fishing spots can be found among the Little Sandy River, Greenbo Lake, and Tygarts Creek. Greenup County's land is still predominantly covered by forest with minimal clear cutting of the old forests.

The soil has long supported a healthy agriculture and livestock industry. Traditionally, this has meant a sizeable tobacco base and cattle ranching. Since the late 20th century, as traditional agriculture products have been dominated by industrial-scale agri-corporations, growth has been seen in non-traditional products such as American Quarter Horses, ostriches, and marijuana.

U.S. Highway 23 is the primary route for travel through Greenup County. It enters Greenup County at the southeasternmost point and follows the Ohio River north along the eastern border passing through Russell, Flatwoods, Raceland, Wurtland, Greenup and South Shore. It then exits just west of South Shore crossing the Ohio River via the U.S. Grant Bridge into Portsmouth, Ohio and continuing north towards Columbus, Ohio.

The AA Highway begins at U.S. Highway 23 and connects to U.S. Highway 52 in Ohio via the Jesse Stuart Memorial Bridge. The AA Highway (also known as Route 10) runs west intersecting Route 7 and eventually exiting west into Lewis County. Since its completion in 1995, the AA Highway has allowed Northeastern Kentucky residents to more easily travel to Maysville, Kentucky as well as Northern Kentucky and Cincinnati, Ohio.

The northern terminus of the Industrial Parkway (Kentucky Route 67) ends at U.S. Highway 23 at Wurtland. This highway serves to connect Wurtland and the surrounding towns of Greenup, Flatwoods and the unincorporated area of Argillite to the EastPark industrial park and Interstate 64 in Carter County.

• Boyd County (southeast)
• Carter County (southwest)
• Lewis County (west)
• Scioto County, Ohio (north)
• Lawrence County, Ohio (east)

Historical population

Census	Pop.	Note	%±
1810	2,369		—
1820	4,311		82.0%
1830	5,852		35.7%
1840	6,297		7.6%
1850	9,654		53.3%
1860	8,760		−9.3%
1870	11,463		30.9%
1880	13,371		16.6%
1890	11,911		−10.9%
1900	15,432		29.6%
1910	18,475		19.7%
1920	20,062		8.6%
1930	24,554		22.4%
1940	24,971		1.7%
1950	24,887		−0.3%
1960	29,238		17.5%
1970	33,192		13.5%
1980	39,132		17.9%
1990	36,742		−6.1%
2000	36,891		0.4%
2010	36,910		0.1%
2020	35,962		−2.6%
2023 (est.)	35,221		−2.1%
U.S. Decennial Census 1790-1960 1900-1990 1990-2000 2010-2020

As of the census of 2000, there were 36,891 people, 14,536 households, and 11,032 families residing in the county. The population density was 107 per square mile (41/km). There were 15,977 housing units at an average density of 46 per square mile (18/km). The racial makeup of the county was 98.07% White, 0.57% Black or African American, 0.19% Native American, 0.38% Asian, 0.15% from other races, and 0.64% from two or more races. 0.55% of the population were Hispanic or Latino of any race.

There were 14,536 households, out of which 32.00% had children under the age of 18 living with them, 62.30% were married couples living together, 10.40% had a female householder with no husband present, and 24.10% were non-families. 21.70% of all households were made up of individuals, and 10.00% had someone living alone who was 65 years of age or older. The average household size was 2.51 and the average family size was 2.91.

In the county, the population was spread out, with 23.60% under the age of 18, 7.90% from 18 to 24, 27.90% from 25 to 44, 26.00% from 45 to 64, and 14.60% who were 65 years of age or older. The median age was 39 years. For every 100 females there were 92.80 males. For every 100 females age 18 and over, there were 89.30 males.

The median income for a household in the county was $32,142, and the median income for a family was $38,928. Males had a median income of $35,475 versus $21,198 for females. The per capita income for the county was $17,137. About 11.60% of families and 14.10% of the population were below the poverty line, including 18.60% of those under age 18 and 9.90% of those age 65 or over.

The current officials of Greenup County are:

• County Judge/Executive: Bobby Hall
• County Commissioner: Ernest Duty
• County Commissioner: Derrick Bradley
• County Commissioner: Lee Wireman
• County Attorney: Matthew Warnock
• County Coroner: L. Neil Wright
• County Jailer: Larry Pancake
• County Treasurer: Sharon Bates
• County Sheriff: Matt Smith
• County Surveyor: Jason Leadingham
• Property Valuation Administrator: Tony Quillen
• County Clerk: Andrew Imel
• Circuit Court Clerk: Allen Reed

Greenup County is a part of the 20th Judicial Circuit (general jurisdiction) and the 20th Judicial District (limited jurisdiction) of the Kentucky Court of Justice (the state's unified court system), which includes neighboring Lewis County. The officials in the 20th Judicial Circuit are:

• Circuit Court, Division 1 (General/Felony Division): Brian C. McCloud
• Circuit Court, Division 2 (Family Court Division): Jeffrey L. Preston
• Commonwealth's Attorney (felony prosecutor): Melvin C. Leonhart

The judge in the 20th Judicial District is:

• District Court: Paul E. Craft

Misdemeanor criminal cases brought in District Court are prosecuted by the County Attorney's office.

United States presidential election results for Greenup County, Kentucky

Year	Republican		Democratic		Third party(ies)
	No.	%	No.	%	No.	%
2024	12,961	74.61%	4,181	24.07%	230	1.32%
2020	13,064	71.88%	4,873	26.81%	239	1.31%
2016	11,546	70.93%	4,146	25.47%	585	3.59%
2012	8,855	58.38%	6,027	39.73%	286	1.89%
2008	8,849	56.01%	6,621	41.91%	328	2.08%
2004	8,696	52.91%	7,630	46.43%	109	0.66%
2000	7,233	49.33%	7,164	48.86%	266	1.81%
1996	5,370	38.48%	6,883	49.32%	1,703	12.20%
1992	4,975	34.52%	7,214	50.05%	2,225	15.44%
1988	6,559	48.38%	6,956	51.31%	43	0.32%
1984	7,451	51.52%	6,923	47.87%	88	0.61%
1980	6,857	48.04%	7,126	49.92%	292	2.05%
1976	5,062	42.14%	6,880	57.27%	71	0.59%
1972	6,828	59.70%	4,491	39.27%	118	1.03%
1968	4,698	43.68%	4,689	43.60%	1,368	12.72%
1964	4,045	37.58%	6,680	62.06%	39	0.36%
1960	6,101	53.77%	5,245	46.23%	0	0.00%
1956	5,464	51.85%	5,045	47.87%	29	0.28%
1952	4,354	47.96%	4,716	51.95%	8	0.09%
1948	3,168	42.48%	4,186	56.13%	104	1.39%
1944	3,718	49.30%	3,821	50.66%	3	0.04%
1940	4,059	45.99%	4,742	53.73%	24	0.27%
1936	3,973	45.88%	4,686	54.12%	0	0.00%
1932	3,422	40.30%	4,963	58.44%	107	1.26%
1928	4,410	64.43%	2,435	35.57%	0	0.00%
1924	2,510	47.30%	1,932	36.41%	864	16.28%
1920	3,111	52.17%	2,754	46.18%	98	1.64%
1916	1,821	48.37%	1,820	48.34%	124	3.29%
1912	923	28.60%	1,172	36.32%	1,132	35.08%

• Greenup County School District serves the cities of Greenup, Wurtland, South Shore and rural Greenup County.
• Russell Independent School District serves the cities of Russell, Flatwoods and Bellefonte.
• Raceland-Worthington Independent School District serves the cities of Raceland and Worthington.

• Lloyd
• South Portsmouth

• EastPark
• Greenbo Lake State Resort Park
• Raceland Race Course

Greenup County is a moist county, meaning that sale of alcohol in the county is prohibited except in certain areas as voted on by the residents of the area, including at least one area where full retail sales are permitted. In the case of Greenup County, alcohol sales are permitted in the following areas:

• The city of Russell has allowed the full retail sale of alcohol since 2014 after allowing, since 2008, by the drink alcohol sales at restaurants which seat at least 100 diners and derive at least 70% of their total sales from food.
• The cities of Greenup, Raceland and South Shore allow full retail sale of alcohol after voters approved local option petitions in 2020.
• The city of Bellefonte has allowed the full retail sale of alcohol since 2017 after allowing, since 2009, the Bellefonte Country Club to sell alcohol by the drink under a provision that allows voters of an otherwise dry precinct to allow alcohol sales at a specific, voter approved, USGA regulation golf course. The status change had no practical effect within the city itself as restaurants (other than the Bellefonte Country Club), liquor stores, gas stations, grocery stores and other businesses that generally sell alcohol are, by local ordinance, prohibited within the city limits of Bellefonte. The change in status allowed the Bellefonte Country Club to receive a "caterer's license" to serve alcohol by the drink at private offsite events, which was not permitted under the previous alcohol status.
• The Hunnewell election precinct in unincorporated Greenup County approved a petition in 2020 allowing the River Bend Golf Course to sell alcohol by the drink under a provision that allows voters of an otherwise dry precinct to allow alcohol sales at a specific, voter approved, USGA regulation golf course.

The sale of alcohol is prohibited in the cities of Flatwoods, Worthington, Wurtland and in all areas of unincorporated Greenup County outside the River Bend Golf Course.

• Billy Ray Cyrus – singer/actor, son of Ron Cyrus and father of Miley Cyrus
• Ron Cyrus – politician
• Don Gullett – Major League Baseball pitcher
• Herb Roe – mural artist
• John Stephenson – Major League Baseball Catcher
• Jesse Stuart – Kentucky Poet Laureate
• Clint "Hawk" Thomas – baseball player for the New York Black Yankees of the Negro leagues
• Richard Whitt - Newspaper journalist, (The Courier-Journal), 1978 Pulitzer Prize for his reporting on the fire at the Beverly Hills Supper Club fire in Southgate, Kentucky.

• National Register of Historic Places listings in Greenup County, Kentucky

• Government website
• The Kentucky Highlands Project
• Detailed Road Map of Greenup County
• Greenup County Tourism and Convention Commission

38°32′N 82°55′W / 38.54°N 82.92°W / 38.54; -82.92