Greenville is the ninth-most populous city in the U.S. state of Mississippi, and the largest city by population in the Mississippi Delta region. It is the county seat of Washington County. The population was 29,670 at the 2020 Census.

This area was occupied by indigenous peoples for thousands of years. When the French explored here, they encountered the historic Natchez people. As part of their colony known as La Louisiane, the French established a settlement at what became Natchez, Mississippi. Other Native American tribes also lived in what is now known as Mississippi.

The current city of Greenville is the third in the State to bear the name. The first, (known as Old Greenville) located to the south near Natchez, was the Jefferson County seat from 1803-1825 but became defunct soon after the American Revolution, as European-American settlement was then still concentrated in the eastern states. This ghost town was in no way related to the second Greenville except that they eventually shared a name.

Many migrants came to the area of the future, second Greenville, located approximately 150 miles north of the first Greenville, from the eastern and Upper South states, seeking land for developing cotton plantations, and this area became a trading center for the region's plantations. In 1830 the United States Congress passed the Indian Removal Act, which authorized the government to make treaties to extinguish Native American land claims in exchange for lands west of the Mississippi River. They forced most of the Southeastern tribes to Indian Territory during the following decade.

After it became necessary to move the county seat of Washington County in 1844 due to loss of land to the newly formed Issaquena County, the not-yet established second Greenville was designated to be the future county seat and finally became so upon its founding in 1847. American William W. Blanton filed for land from the United States government and was granted section four, township eighteen, range eight west; this plot now constitutes most of current downtown Greenville (the third). It was named by its founders for General Nathanael Greene, friend of President George Washington, for whom the county was named. This Greenville was thriving hamlet in the antebellum years, as cotton plantations developed in the area generated high profits for major planters. They used indentured Whites, captured Indians and African slaves as farmhands on the plantations.

Washington County's two previous county seats, New Mexico and Princeton, were located along the Mississippi River and had been eroded by the waters, to the point that they were destroyed. As county seat, Greenville was the trading, business, and cultural center for the large cotton plantations that surrounded it. Most plantations were located directly on the Mississippi and other major navigable tributaries. The interior bottomlands were not developed until after the Civil War.

The town (the second Greenville, eventually also referred to as Old Greenville by its residents who may not have been familiar with Mississippi's first Greenville, which by then had disappeared) was destroyed during the Union Army's actions related to the siege of Vicksburg. Troops from a Union gunboat landed at Greenville. In retaliation for being fired upon, they burned every building. The inhabitants took refuge in plantation homes of the area. When the war ended, veterans of Mississippi regiments returned to find Greenville in a state of ruin.

The former residents soon decided to build again. They chose a new site (the third, current Greenville) three miles away, at the highest point on the Mississippi River between the towns of Vicksburg and Memphis. Much of the land belonged to the Roach and Blanton families; the major part of the area selected was within property owned by Mrs. Harriet Blanton Theobald. She welcomed the idea of a new Greenville, and donated land for schools, churches and public buildings. She was called the "Mother of Greenville". Major Richard O’Hea, who had planned the wartime defense fortifications at Vicksburg, was hired to lay out the new town.

Greenville recovered prosperity, still based on cotton, despite the decline in world markets for this commodity. In the early 20th century, its elite families had considerable political influence in the state, and US Senator Leroy Percy was from here. Several residences and other buildings from the late 19th and early 20th centuries have been listed on the National Register of Historic Places. It was a center of Delta culture in the early 20th century. This city adapted the former site to serve as industrial fill.

African Americans in the Delta developed rich varieties of innovative music. Nelson Street is a historic strip of blues clubs that drew crowds in the 1940s and 1950s to the flourishing club scene to hear Delta blues, big band, jump blues and jazz. Record companies came to Greenville to recruit talent. It was similar to Beale Street in mid-20th century Memphis.

In the early 21st century, the Mississippi Blues Commission was established to commemorate this music in the state's history and culture. It has identified sites throughout the Delta as part of the Mississippi Blues Trail.

Southern Whispers Restaurant on Nelson Street in Greenville was the second site identified on this trail; this was a stop on the Chitlin' Circuit in the early days of the blues. The historic marker in front of the restaurant commemorates its importance in the history of the blues in Mississippi.

In 2020 the city ordered churches to shut down to prevent the spread of COVID-19 and issued citations and fines to those attending a drive-in church gathering. The U.S. Justice Department intervened on behalf of the church.

Greenville is located on the eastern bank of Lake Ferguson, an oxbow lake left from an old channel of the Mississippi River.

One floating casino is located on the lake near the downtown area known as the Trop Casino Greenville, with a second just west of the city near the Greenville Bridge known as Harlow's Casino Resort. Chicago Mill and Lumber Co. operated a lumber mill on the lake two-tenths of a mile south of the casino levee parking lot; the mill specialized in making hardwood boxes until it closed.

According to the United States Census Bureau, the city has a total area of 27.7 square miles (72 km), of which 26.9 square miles (70 km) is land and 0.8 square miles (2.1 km) (2.82%) is water.

Historical population

Census	Pop.	Note	%±
1860	760		—
1870	890		17.1%
1880	2,191		146.2%
1890	6,658		203.9%
1900	7,642		14.8%
1910	9,610		25.8%
1920	11,560		20.3%
1930	14,807		28.1%
1940	20,892		41.1%
1950	29,936		43.3%
1960	41,502		38.6%
1970	39,648		−4.5%
1980	40,613		2.4%
1990	45,226		11.4%
2000	41,633		−7.9%
2010	34,400		−17.4%
2020	29,670		−13.7%
2023 (est.)	27,644		−6.8%
Sources: U.S. Decennial Census

Greenville Racial Composition

Race	Num.	Perc.
White	4,821	16.25%
Black or African American	23,787	80.17%
Native American	33	0.11%
Asian	264	0.89%
Pacific Islander	3	0.01%
Other/Mixed	493	1.66%
Hispanic or Latino	269	0.91%

As of the 2020 United States Census, there were 29,670 people, 12,142 households, and 7,405 families residing in the city.

As of the 2013 American Community Survey, there were 33,928 people living in the city. 75.9% were African American, 21.7% White, 0.0% Native American, 0.8% Asian, 0.9% from some other race and 0.7% from two or more races. 1.2% were Hispanic or Latino of any race.

As of the census of 2000, there were 41,633 people, 18,784 households, and 14,422 families living in the city. The population density was 1,548.8 inhabitants per square mile (598.0/km). There were 16,251 housing units at an average density of 604.6 per square mile (233.4/km). The racial makeup of the city was 28.92% White, 69.60% Black, 0.07% Native American, 0.71% Asian, 0.01% Pacific Islander, 0.20% from other races, and 0.49% from two or more races. Hispanic or Latino of any race were 0.71% of the population.

There were 14,784 households, out of which 35.8% had children under the age of 18 living with them, 37.8% were married couples living together, 27.7% had a female householder with no husband present, and 29.5% were non-families. Of all households, 25.8% were made up of individuals, and 10.4% had someone living alone who was 65 years of age or older. The average household size was 2.77 and the average family size was 3.34.

In the city, the population was spread out, with 31.4% under the age of 18, 10.1% from 18 to 24, 26.3% from 25 to 44, 20.5% from 45 to 64, and 11.8% who were 65 years of age or older. The median age was 32 years. For every 100 females, there were 85.4 males. For every 100 females age 18 and over, there were 77.5 males.

The median income for a household in the city was $25,928, and the median income for a family was $30,788. Males had a median income of $29,801 versus $20,707 for females. The per capita income for the city was $13,992. About 25.7% of families and 29.6% of the population were below the poverty line, including 38.2% of those under age 18 and 23.6% of those age 65 or over.

As of the census of 1990, there were 45,226 people living in the city. The racial makeup of the city was 59.41% (26,867) Black or African American, 39.54% (17,881) White, 0.08% (37) Native American, 0.41% (185) Asian, and 0.01% (4) from other races. 0.56% (252) were Hispanic or Latino of any race.

Mayors of Greenville, Mississippi

Image Mayor Years Notes ? 1824–? L. Wilczinski 1875–1887 R. W. Tilford 1887–1889 J. H. Wynn 1889–? –? J. T. Gooch December 1919 – July 15, 1920 Resigned effective July 15, 1920 due to the need to conduct business away from the city J. Allen Hunt July 15, 1920 – ? Appointed mayor after resignation of J.T. Gooch ? Fred Schelben 1928–1932 E. G. Ham 1932–1934 Milton C. Smith 1934–1944 E. M. Gray 1944–1948 George F. Archer 1948–1964 Pat Dunne 1964–1976 William Burnley 1976– July 31, 1990 Defeated in a runoff election He was authorized to serve until August 8, 1990 but resigned effective July 31, 1990. Jerre Lane July 31, 1990 – August 8, 1990 Vice Mayor Lane served as interim mayor after William Burnley's resignation Frank Self August 8, 1990 – 1995 Paul Artman Jr. 1996–2003 Heather McTeer Toney 2004–2011 First African-American mayor Chuck Jordan 2012 Resigned effective September 24, 2012 after being diagnosed with pancreatic cancer. Carolyn Weathers September 24, 2012 – October 24, 2012 Vice Mayor Weathers served as interim mayor after Chuck Jordan's resignation John Cox October 24, 2012 – 2014 Elected in a special election on October 22, 2012 to complete Jordan's term; sworn in on October 24, 2012. Errick Simmons 2015–Present 2nd African-American mayor

Greenville Mid Delta Regional Airport, located in unincorporated Washington County, northeast of downtown Greenville, serves the city and the Mississippi Delta region. Commercial passenger air service is currently provided by Contour Airlines with nonstop Embraer regional jet flights to Dallas/Fort Worth (DFW) and Nashville (BNA).

U.S. Highway 61, U.S. Highway 82 and the Great River Road (Mississippi Highway 1) are the main transportation arteries through the Greenville area. U.S. Highway 82 is a major part of the Mississippi Delta's transportation network, as it connects to Interstate 55 and other major four-lane highways. In addition, the U.S. Highway 82 bypass is being constructed to provide a transportation route at the southern end of the Delta, connecting at the new Mississippi River Bridge and ending near Leland. The four-lane Greenville Bridge, a $206 million cable-stayed span crossing the Mississippi River into Arkansas, opened in 2010, replacing the two-lane Benjamin G. Humphreys Bridge, which opened in 1940.

The Columbus and Greenville Railway operates the Greenwood–Greenville rail line for freight traffic. North of Greenville, the Great River Railroad's line to Rosedale branches off.

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Circa 2008 there were ten grocery stores operated by ethnic Chinese people. There were 42 such stores in the city in 1951, but since then there had been a flight of ethnic Chinese from the Delta.

Most of Greenville is served by the Greenville Public School District, while a small portion of the city lies in the Western Line School District. Greenville High School is the public high school of the Greenville district, while O'Bannon High School serves Western Line residents.

The private schools, Washington School and Greenville Christian School, also serve the city, as well as St. Joseph Catholic School (K-12), a parochial school which is part of the Roman Catholic Diocese of Jackson. The diocese formerly operated Our Lady of Lourdes Elementary School, which merged into St. Joseph in 2016.

The Greenville Higher Education Center offers non-credit community courses and credit courses from Delta State University, Mississippi Delta Community College (MDCC), and Mississippi Valley State University. All of Washington County is in the service area of MDCC.

Delta Democrat Times is the daily newspaper of the town.

The Greenville Bucks were a minor-league baseball team in the Cotton States League from 1922 to 1955.

The Greenville Bluesmen were an independent minor league professional baseball team from 1996–2001 in Greenville.

The Mississippi Miracles, formerly the Mississippi Stingers, were an American Basketball Association franchise from 2004–2006 in Greenville.

Greenville will become host to a mega-sports complex for young athletes.

The Winterville Mounds Historic Site, with more than twelve earthwork mounds constructed by people of the Plaquemine Mississippian culture, is a survival north of the county seat of the deep indigenous history along the Mississippi River. This culture was particularly prominent from 13th to the 15th centuries, long before European exploration. Earthwork mounds were built by peoples in this area from the 9th century. The people in this region were influenced by the larger Mississippian culture, which built similar ceremonial sites throughout the Mississippi Valley and its tributaries. The historic Natchez people are considered the only contemporary surviving group of the Mississippian culture at the time of European exploration.

The Winterville Mounds has been designated as a state park and National Historic Landmark. A museum on the grounds displays artifacts recovered in professional excavations and adds to the interpretation of this complex, and the park has walking trails. It is located about 3 miles north of the city. It can be reached at 2415 Highway 1 N.

The movies Crossroads (1986) and The Reivers (1969) were filmed in Greenville. Also, the 1975 song "Mississippi" by the Dutch band Pussycat mentions Greenville throughout the song.

The movie Django Unchained (2012) is set in Greenville for some scenes.

• Quentin Groves, (1984–2016) was an American football linebacker, drafted by the Jacksonville Jaguars in the second round of the 2008 NFL. Groves was a sack specialist at Auburn and finished tied for the Auburn career sack record at 26.
• Steve Azar, country singer
• Heather McTeer Toney, former mayor of Greenville and EPA regional administrator.
• John Colbert, a.k.a. J Blackfoot, Soul singer with the Bar-Kays and Soul Children, was born in Greenville.
• Eden Brent, blues boogie-woogie musician, composer, and performer
• Vivian Brown, meteorologist for The Weather Channel
• Charles Chew, (1922–1986), Illinois state senator; born in Greenville
• Tommy Davidson, actor/comedian
• Ross Davis, Negro league baseball player
• Tyrone Davis, blues musician
• Johnny Dollar, (1941–2006), Chicago blues guitarist, singer and songwriter
• Shelby Foote, author and historian
• Jimmie Giles, NFL tight end, four-time Pro Bowl selection in the 1980s with Tampa Bay Buccaneers
• Brooks Haxton, poet and professor at Syracuse University
• Robert T. Henry, World War II soldier and Medal of Honor recipient
• Jim Henson, (1936–1990), puppeteer, television and film producer, creator of The Muppets
• Corey Holmes, all-star Canadian Football League player and Mayor of Metcalfe, Mississippi
• Lucy Somerville Howorth, feminist and New Deal lawyer
• Carla Hughes, convicted of murdering Avis Banks and her unborn baby.
• Antonio Johnson, NFL player for the Indianapolis Colts
• Germany Kent, model and media personality
• Cornelia Lampton, pianist
• Sam Chu Lin, pioneering Chinese American journalist
• John Ramsey Miller, writer and journalist
• Wilbert Montgomery, former NFL running back, member of Philadelphia Eagles Hall of Fame
• The Percy family, including U.S. Senator Le Roy Percy and his son, author William Alexander Percy, lived here. They directed efforts to prevent and recover from the Great Mississippi Flood of 1927. The younger Percy wrote a memoir, Lanterns on the Levee about the Mississippi Delta culture. Walker Percy, another writer from the Percy family, and his brothers were raised by William Alexander Percy here after being orphaned. He lived most of his life in Louisiana.
• Neil Ratliff (1936-1994), music librarian
• Julia Evans Reed, author, journalist and columnist
• George Scott, MLB player for Boston Red Sox, Milwaukee Brewers, Kansas City Royals and New York Yankees
• Carol Schwartz, former member of Council of the District of Columbia
• Nellie Nugent Somerville, first woman elected to Mississippi Legislature, mother of Lucy Somerville Howorth
• LaToya Thomas, former professional basketball player in WNBA, first round draft pick of Cleveland Rockers
• Walter Turnbull, African American musician, founder of Boys Choir of Harlem, as well as a Mississippi Musicians Hall of Fame inductee, was born in Greenville in 1944
• Frank White, professional baseball player
• Mary Wilson, singer of The Supremes
• Benjamin_Wright_(composer), (born July 11, 1946) is an American record producer, composer and arranger.As an arranger, he has conducted hits for many artists including Justin Timberlake, OutKast, Brandy, Destiny's Child, Dru Hill, Aretha Franklin, Quincy Jones, James Ingram, Richard Ashcroft, Janet Jackson and Michael Jackson.
• Malcolm Wynn, first black police chief of Greenville Police Department
• Kelvin Jones, director of the LSU Tiger Band and first African American head athletic band director in SEC history

• Ray Brown, NFL football player
• Hodding Carter, Pulitzer Prize-journalist, managed the city's Delta Democrat Times. His descendant Hodding Carter III, also a journalist, lived and worked here during and after the civil rights movement.
• Holt Collier is buried in Greenville. Collier was an African-American bear hunter and sportsman; he served as the guide for President Theodore Roosevelt on a bear hunt in Sharkey County. In January 2004 the Holt Collier National Wildlife Refuge was established on Collier's "historic hunting grounds" south of Greenville.
• Samuel Gibbs French (1818-1910), Confederate Major General, managed a plantation in Greenville
• John F. Harris, Mississippi State Representative from Greenville elected in 1890.
• Clarke Reed, Mississippi state Republican chairman from 1966 to 1976, was instrumental in the nomination of Gerald R. Ford, Jr., at the 1976 Republican National Convention, has resided in Greenville since 1950; he is a businessman and investor.
• Sam Stein, Russian Jewish immigrant who founded the retail store chain Stein Mart
• Thomas R. Yarborough, first Black city councilman in California

• Kronach, Bavaria, Germany, since 2006
• Greenville, Liberia, since 2009

• List of municipalities in Mississippi

• City of Greenville
• Delta Democrat-Times
• History of Greenville's Jewish community (from the Institute of Southern Jewish Life)
• "Greenville, a city and the county-seat of Washington county, Mississippi, U.S.A." . Encyclopædia Britannica (11th ed.). 1911.