Große Kulmke is a river of Lower Saxony, Germany.

The Große Kulmke is a tributary of the Sieber in central Germany. It rises near the natural monument of Mönchskappenklippe near the ridge of Auf dem Acker, north-northeast of Sieber in the district of Göttingen in Lower Saxony. It then flows mainly in a southerly direction, separated from the Sieber by the Königsberg. After 5 km (3.1 mi) it merges with the Kleine Kulmke at an elevation of 392 m (1,286 ft). The valley of the Große Kulmke is part of the Sieber Valley (Siebertal) nature reserve.

• List of rivers of Lower Saxony

• Topographische Karte 1:25000, No. 4228 Riefensbeek

• Sieber Valley Nature Reserve at the website of the Lower Saxon State Department for Waterway, Coastal and Nature Conservation (NLWKN) (in German)