Großer Pälitzsee is a lake in the Mecklenburgische Seenplatte district in Mecklenburg-Vorpommern, Germany. At an elevation of 56.1 metres (184 ft), its surface area is 2.58 square kilometres (1.00 sq mi).

At Strasen, at the eastern end of the lake, a canal and lock gives access to the Ellbogensee and the navigable River Havel.