Grudynia Wielka [ɡruˈdɨɲa ˈvjɛlka] is a village in the administrative district of Gmina Pawłowiczki, within Kędzierzyn-Koźle County, Opole Voivodeship, in south-western Poland. It lies approximately 22 km (14 mi) south-west of Kędzierzyn-Koźle and 49 km (30 mi) south of the regional capital Opole.