Guadalajara Centro railway station is the ninth station of Line 3 of Guadalajara's SITEUR from south-east to north-west, and the tenth in the opposite direction; it is also a station with a large influx of passengers because it acts as a transfer station with Plaza Universidad on Line 2 of the system.

This station is located under 16 de Septiembre Avenue, between Eje Morelos (which separates Juárez and Hidalgo Guadalajara sectors) and Juárez Avenue (under which Line 2 runs). During the construction of Line 3 it was necessary to reinforce the structural box that includes the Line 2 tunnel that runs above the structural tunnel corresponding to Line 3; for this, sections called Milan Walls were built.

The station logo is the image of the Metropolitan Cathedral with three colors: the first is pink due to the color of Line 3, the second color is green for the transfer to Line 2 and the last color is red for the transfer to SITREN [es] Lines 1 and 3.

• 
  Guadalajara Cathedral, located over the Guadalajara Centro station
• 
  Exit to Plaza Guadalajara
• 
  Entrance location (far right) at the Plaza de Armas
• Line 3 train arriving to Guadalajara Centro station

• Metropolitan Cathedral
• Former Cloister of San Agustín (CUAAD Music Department)
• Former Cloister of Santa María de Gracia (CUAAD Plastic Arts School)
• Government Palace
• Municipal Palace
• Legislative Palace (Congress of Jalisco)
• Regional Museum
• Teatro Degollado
• Rotonda de los Jaliscienses Ilustres
• Octavio Paz Ibero-American Public Library
• Plaza de La Liberación
• Plaza Guadalajara
• Plaza de Armas
• Mercado Corona
• Edificio Camarena
• Museo de Cera (Wax Museum)